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A common question is how much should we expect the blood glucose concentration to increase after dextrose 50% (D50) administration. Fortunately, there is an answer from 3 studies. Balentine JR,...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Urine drug tests are commonly sent for patients in the emergency department, however care should be taken when interpreting the results of these tests given their limitations. The American...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Acute agitation in the emergency department is a common issue that frequently requires the use of chemical sedation to preserve safety for patients and healthcare workers. A commonly employed...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Direct-acting oral anticoagulants (DOACs), including apixaban, rivaroxaban, edoxaban, and dabigatran, are widely used for various indications and considered first-line therapy for prevention of acute ischemic stroke in patients with...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background An acute aortic dissection (AAD) can be a life-threatening emergency which frequently requires rapid and precise control of the patient’s heart rate and blood pressure. The 2010 guidelines for...
Mike O'Brien, PharmD |
Background Caring for a patient that is critically-ill secondary to a toxic ingestion is complicated and, in severe cases, extracorporeal treatments (ECTRs) may be considered. The most commonly used ECTRs...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Two new oral agents were given Emergency Use Authorization to be used in patients with mild-moderate COVID-19 at high risk of progression to severe infection, molnupiravir and nirmatrelvir/ritonavir (Paxlovid)...
Mike O'Brien, PharmD |
Background Many guidelines and treatment algorithms for diabetic ketoacidosis (DKA) recommend sodium chloride 0.9% as the replacement fluid of choice, though alternative fluids may be a better option [1-4]. Randomized...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Early antibiotics are recommended for treatment of many infections, including patients with sepsis or septic shock [1]. Critically-ill patients and those with a suspected infection at risk for severe...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Treatment of digoxin toxicity can be quite complex and generally involves the use of digoxin immune Fab (DigiFab®) for symptomatic patients. The dosing of DigiFab can vary depending on...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
Background Sodium bicarbonate during a cardiac arrest is widely debated and used in many cases. In a 2018 PULMCrit post, Dr. Josh Farkas reviews much of the data regarding this...
Mike O'Brien, PharmD |
Background Bleeding patients or those undergoing procedures that are at high risk of bleeding may require correction of their INR. Multiple products can be used to achieve this, including fresh...
Mike O'Brien, PharmD |
Background Succinylcholine is frequently used in the ED to facilitate intubation, but it may be avoided in some cases due to the risk of hyperkalemia. The underlying physiology of this...
Bryan D. Hayes, PharmD, DABAT, FAACT, FASHP |
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