To provide a resource for evidence-based Emergency Medical education, this list of must-read landmark articles was created to supplement the Emergency Medicine (EM) internship year of training. There are 52 articles so that one article can be read at leisure each week of the year. I searched national databases and polled faculty at the University of Washington to identify articles that faculty would expect any EM resident to be familiar with or that they felt were practice-changing in EM. Articles were selected for the final list based on the quality of study design, sample size, and relevance for EM residents.
| System | Autdors | Title | Journal | Year | Abstract |
| Airway/ Respiratory | Reed, MJ et al | Can an Airway Assessment Score Predict Difficulty at Intubation in the Emergency Department? | Emergency Medicine Journal | 2005 | Pubmed |
| Airway/ Respiratory | Wells, PS et al | Excluding pulmonary embolism at the bedside without diagnostic imaging: Management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer. | Annals of Internal Medicine | 2001 | Pubmed |
| Airway/ Respiratory | Kheterpal, S et al | Incidence and Predictors of Difficult and Impossible Mask Ventilation. | Anesthesiology | 2006 | Pubmed |
| Airway/ Respiratory | The Acute Respiratory Distress Syndrome Network | Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. | New England Journal of Medicine | 2000 | Pubmed |
| Airway/ Respiratory | Burton, JH et al | Does End-Tidal Carbon Dioxide Monitoring Detect Respiratory Events Prior to Current Sedation Monitoring Practices? | Academic Emergency Medicine | 2006 | Pubmed |
| Airway/ Respiratory | Brochard, L et al | Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease. | New England Journal of Medicine | 1995 | Pubmed |
| Airway/ Respiratory | Kline, JA et al | Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. | Journal of Thrombosis and Haemostasis | 2008 | Pubmed |
| Airway/ Respiratory | Weingart, SD et al | Preoxygenation and prevention of desaturation during emergency airway management. | Annals of Emergency Medicine | 2012 | Pubmed |
| Cardiology | Mehta, S et al | Routine vs Selective Invasive Strategies in Patients with Acute Coronary Syndromes: A Collaborative Meta-Analysis of Randomized Trials. | Journal of the American Medical Association | 2005 | Pubmed |
| Cardiology | Sgarbossa, E et al | Electrocardiographic Diagnosis of Evolving Acute Myocardial Infarction in the Presence of Left Bundle-Branch Block. | New England Journal of Medicine | 1996 | Pubmed |
| Cardiology | Weigner, M et al | Risk for Clinical Thromboembolism Associated with Conversion to Sinus Rhythm in Patients with Atrial Fibrillation Lasting Less than 48 Hours. | Annals of Internal Medicine | 1997 | Pubmed |
| Cardiology | Than, M et al | 2-Hour Accelerated Diagnostic Protocol to Assess Patients With Chest Pain Symptoms Using Contemporary Troponins as the Only Biomarker: The ADAPT Trial. | Journal of the American College of Cardiology | 2012 | Pubmed |
| Cardiology | Quinn, J et al | Prospective validation of the San Francisco Syncope Rule to predict patients with serious outcomes. | Annals of Emergency Medicine | 2006 | Pubmed |
| Cardiology | Wenzel, V et al | A Comparison of Vasopressin and Epinephrine for Out-of-Hospital Cardiopulmonary Resuscitation. | New England Journal of Medicine | 2004 | Pubmed |
| Cardiology | Hypothermia After Cardiac Arrest Study Group | Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest. | New England Journal of Medicine | 2002 | Pubmed |
| Cardiology | Wyse, DG et al | A comparison of rate control and rhythm control in patients with atrial fibrillation. | New England Journal of Medicine | 2002 | Pubmed |
| Cardiology | Andersen, HR et al | A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. | New England Journal of Medicine | 2003 | Pubmed |
| Gastrointestinal | Palamidessi, N et al | Nasogastric aspiration and lavage in emergency department patients with hematochezia or melena without hematemesis. | Academic Emergency Medicine | 2010 | Pubmed |
| Gastrointestinal | Villanueva, C et al | Transfusion strategies for acute upper gastrointestinal bleeding. | New England Journal of Medicine | 2013 | Pubmed |
| Gastrointestinal | Lau, J et al | Omeprazole Before Endoscopy in Patients with Gastrointestinal Bleeding. | New England Journal of Medicine | 2007 | Pubmed |
| Immunology | Lin, R et al | Improved Outcomes in Patients with Acute Allergic Syndromes Who are Treated with Combined H1 and H2 Antagonists. | Annals of Emergency Medicine | 2000 | Pubmed |
| Infectious disease | Marik, PE et al | The risk of catheter-related bloodstream infection with femoral venous catheters as compared to subclavian and internal jugular venous catheters: A systematic review of the literature and meta-analysis. | Critical Care Medicine | 2012 | Pubmed |
| Infectious disease | Medeiros, I and Saconato, H. | Antibiotic prophylaxis for mammalian bites. | Cochrane Database of Systematic Reviews | 2001 | Pubmed |
| Infectious disease | Wong, C et al | The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. | Critical Care Medicine | 2004 | Pubmed |
| Musculoskeletal | Stiell, IG et al | Decision Rules for the Use of Radiography in Acute Ankle Injuries. | Journal of the American Medical Association | 1993 | Pubmed |
| Neuroscience | Anderson, CS et al | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. | Lancet | 2008 | Pubmed |
| Neuroscience | Perry, JJ et al | High risk clinical characteristics for subarachnoid haemorrhage in patients with acute headache: prospective cohort study. | British Medical Journal | 2010 | Pubmed |
| Neuroscience | Johnston, SC et al | Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. | Lancet | 2007 | Pubmed |
| Neuroscience | Morgenstern, L et al | Worst Headache and Subarachinoid Hemorrhage: Prospective, Modern Computed Tomography and Spinal Fluid Analysis. | Annals of Emergency Medicine | 1998 | Pubmed |
| Neuroscience | The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. | Tissue plasminogen activator for acute ischemic stroke. | New England Journal of Medicine | 1995 | Pubmed |
| Neuroscience | Hacke, W et al | Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. | New England Journal of Medicine | 2008 | Pubmed |
| Pediatrics | Holmes, J et al | Validation of a Prediction Rule for the Identification of Children With Intra-abdominal Injuries After Blunt Torso Trauma. | Annals of Emergency Medicine | 2009 | Pubmed |
| Pediatrics | Kuppermann, N et al | Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. | Lancet | 2009 | Pubmed |
| Pediatrics | Altamimi, S et al | Single-dose oral dexamethasone in the emergency management of children with exacerbations of mild to moderate asthma. | Pediatric Emergency Care | 2006 | Pubmed |
| Pediatrics | Berg, AT et al | A Prospective Study of Recurrent Febrile Seizures. | New England Journal of Medicine | 1992 | Pubmed |
| Renal/ urology | Coll, DM et al | Relationship of spontaneous passage of ureteral calculi to stone size and location as revealed by unenhanced helical CT. | American Journal of Roentgenology | 2002 | Pubmed |
| Renal/ urology | Luchs, JS et al | Utility of hematuria testing in patients with suspected renal colic: correlation with unenhanced helical CT results. | Urology | 2002 | Pubmed |
| Resuscitation | Dellinger, RP et al | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock. | Critical Care Medicine | 2013 | Pubmed |
| Resuscitation | Rivers, E et al | Early goal-directed therapy in the treatment of severe sepsis and septic shock. | New England Journal of Medicine | 2001 | Pubmed |
| Resuscitation | Jones, AE et al | Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. | Journal of the American Medical Association | 2010 | Pubmed |
| Trauma | Hoffman, JR et al | Selective cervical spine radiography in blunt trauma: methodology of the National Emergency X-Radiography Utilization Study (NEXUS). | Annals of Emergency Medicine | 1998 | Pubmed |
| Trauma | Bickell, WH et al | Immediate Versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries. | New England Journal of Medicine | 1994 | Pubmed |
| Trauma | Stiell, IG et al | The Canadian C-Spine Rule for Radiography in Alert and Stable Trauma Patients. | Journal of the American Medical Association | 2001 | Pubmed |
| Trauma | Stiell, IG et al | The Canadian CT Head Rule for patients with minor head injury. | Lancet | 2001 | Pubmed |
| Trauma | Chi, JH et al | Prehospital Hypoxia Affects Outcome in Patients with Traumatic Brain Injury: A Prospective Multicenter Study. | Journal of Trauma | 2006 | Pubmed |
| Trauma | Haydel, MJ et al | Indications for Computed Tomography in Patients with Minor Head Injury. | New England Journal of Medicine | 2000 | Pubmed |
| Trauma | CRASH-2 trial collaborators | Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. | Lancet | 2010 | Pubmed |
| Trauma | Branney, SW et al | Critical Analysis of Two Decades of Experience with Postinjury Emergency Department Thoracotomy in a Regional Trauma Center. | Journal of Trauma | 1998 | Pubmed |
| Trauma | Tsutsumi, S et al | Effects of the Second National Acute Spinal Cord Injury Study of High-Dose Methylprednisolone Therapy on Acute Cervical Spinal Cord Injury-Results in Spinal Injuries Center. | Spine | 2006 | Pubmed |
| Trauma | MacKenzie, EJ et al | A national evaluation of the effect of trauma-center care on mortality. | New England Journal of Medicine | 2006 | Pubmed |
| Ultrasound | Branney, SW et al | Quantitative Sensitivity of Ultrasound in Detecting Free Intraperitoneal Fluid. | Journal of Trauma | 1995 | Pubmed |
| Ultrasound | Nagdev, AD et al | Emergency department bedside ultrasonographic measurement of the caval index for noninvasive determination of low central venous pressure. | Annals of Emergency Medicine | 2010 | Pubmed |
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