Your Cart ()
cload

GUARANTEED SAFE & SECURE CHECKOUT

Spend $x to Unlock Free Shipping to  

Extracellular Vesicles to Protect Lungs and Brain in Premature Birth

By Conn Hastings April 05, 2022 0 comments

Researchers at the Ottawa Hospital in Canada have been investigating the potential of extracellular vesicles that are derived from umbilical cord mesenchymal stromal cells (MSCs) to protect the lungs and brain in very premature babies. Such babies require supplemental oxygen, but this can damage their lungs, causing a condition called bronchopulmonary dysplasia (BPD). In the meantime their brains are also at risk because of low oxygen. These researchers have been investigating the potential of MSCs to help protect and regenerate such tissues, and a recent study in mice suggests that extracellular vesicles from such cells could provide therapeutic benefit. The technique could be invaluable, as the vesicles are much easier to administer, store, and manufacture.

Mesenchymal stromal cells, also known as mesenchymal stem cells, have significant therapeutic potential. Despite this, clinicians and researchers have yet to convert this potential into mainstream clinical treatments. Part of the issues lies in the fact that such cells are delicate, living structures, and require careful handling and maintenance to keep them alive and maintain their ability to provide therapeutic benefits. Other practical considerations have hampered cell therapies, since the cells are not easily obtained or stored, reducing their usefulness for routine treatments.

Happily, the cells release nano-sized extracellular vesicles that are easier to handle and store and may also have therapeutic potential. Interestingly, they can also cross the blood brain barrier, unlike MSCs, and so may have potential in treating issues in the brain. In this latest study, researchers based at the Ottawa Hospital have tested their potential in a mouse model of BPD, a chronic lung disease affecting very premature babies. In a cruel irony, the oxygen used to treat premature babies can end up injuring their lungs, leading to BPD. Meanwhile, a lack of oxygen getting to the brain can result in developmental issues.

In this new study, the researchers investigated if MSC-derived extracellular vesicles could alleviate both issues in mice with simulated BPD. Excitingly, the extracellular vesicles acted to prevent both lung and brain injury. “A therapy that improves lung and brain health would immensely benefit preterm babies with this chronic lung disease,” said Bernard Thébaud, a researcher involved in the study.       

The Ottawa team is currently performing a clinical study investigating the use of MSCs in preterm babies, and given the positive results of the current study, they hope to also test MSC-derived extracellular vesicles in this context.

See a video about using MSCs to treat premature babies below.

Study in American Journal of Respiratory and Critical Care Medicine: Pulmonary and Neurologic Effects of Mesenchymal Stromal Cell Extracellular Vesicles in a Multifactorial Lung Injury Model

Via: The Ottawa Hospital


Older Post Newer Post

Newsletter

I agree to subscribe to updates from Shoptimized™

Categories

B. Dupont Purchased 1 minute ago from Los Angeles, CA
2
C. Santos Purchased 1 minute ago from Chicago, IL
5.11 FLEX TacMed Pouch
D. Kim Purchased 1 minute ago from Houston, TX
5.11 FLEX Tourniquet Pouch
E. García Purchased 2 minutes ago from Phoenix, AZ
5.11 UCR TacReady Headrest Pouch
F. Müller Purchased 1 minute ago from Philadelphia, PA
Abdominal Aortic and Junctional Tourniquet-Stabilized (AAJT-S)
G. Rossi Purchased 2 minutes ago from San Antonio, TX
Adjustable Flange Nasopharyngeal Airway
H. Martinez Purchased 1 minute ago from San Diego, CA
Adult Bag Valve Mask
J. López Purchased 2 minutes ago from Dallas, TX
Altama OTB Maritime Assault Boot - Low Height
K. Nowak Purchased 2 minutes ago from San Jose, CA
Altama OTB Maritime Assault Boot - Mid Height
L. Müller Purchased 2 minutes ago from Austin, TX
AMBU Perfit ACE Adjustable Cervical Extrication Collar
M. Ivanova Purchased 1 minute ago from Jacksonville, FL
Amphibious Trauma Kit
N. Andersen Purchased 1 minute ago from Fort Worth, TX
Army CLS Resupply Kit (CLS™)
O. Fischer Purchased 1 minute ago from Columbus, OH
Backpack Accessory Pouch Kit - 4 Color
P. Bernard Purchased 2 minutes ago from Charlotte, NC
Ballistic Soft Panel for Plate Carrier
S. Schmidt Purchased 1 minute ago from San Francisco, CA
Bandage Fill Kit
T. Kowalski Purchased 2 minutes ago from Indianapolis, IN
Bandage Shears
X. Martinez Purchased 2 minutes ago from Seattle, WA
Bard-Parker Safety Scalpel #10
Y. Ahmed Purchased 1 minute ago from Denver, CO
Basic Field Surgical Airway Kit w/ET Tube
Z. Khan Purchased 2 minutes ago from Washington, DC
Beacon Chest Seal - Occlusive/Non-Vented
A. Ali Purchased 2 minutes ago from Boston, MA