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REBEL Cast Ep110: The COVI-PRONE Trial – Awake Prone Positioning and COVID-19
by Marco Torres
Jun 20, 2022
Background: Early in the COVID-19 pandemic, clinicians were looking for practical, widely available, and low-cost interventions to help patients wi...
Tactical Medicine News
SSRIs and COVID-19
Background: The effects of the COVID-19 pandemic have been devastating. Given the novelty of the virus, only a few effective treatments have emerge...
Tactical Medicine News
The INSPIRATION Trial: Intermediate Dose Anticoagulation in Critically Ill Patients with COVID-19
Background: COVID-19 infection increases the risk of thrombosis due to multiple factors.(Rico-Mesa, 2020). Over the last 2 years, researchers hav...
Tactical Medicine News
The COV-BOOST Trial: Safety and Immunogenicity of Boosters
Background: COVID-19 became an international pandemic in March of 2020, claiming the lives of millions of people worldwide. To combat this deadly v...
Tactical Medicine News
The ACTION Trial: DOACs in Hospitalized Patients with COVID-19
Background: Patients hospitalized with COVID-19 are at increased risk for both arterial and venous thromboembolic disease. Multiple recent trials h...
Tactical Medicine News
The MICHELLE Trial: Anticoagulation Post-Discharge in Patients Hospitalized Secondary to COVID-19
Background: Patients diagnosed with COVID-19 have an increased risk of thromboembolic events, including pulmonary embolism and deep vein thrombosis...
Tactical Medicine News
The MOVe-Out Trial: Molnupiravir – Oral Antivirals for Management of Covid-19?
Background: On December 23, 2021, the FDA granted molnupiravir emergency use authorization for the treatment of patients with Covid-19. Molnupiravi...
Tactical Medicine News
The ACTIV-4b Trial: Antithrombotics For Treatment of Outpatient COVID-19
Background: Severely ill patients diagnosed with COVID-19 have an increased risk of cardiovascular complications, especially thromboembolic events ...
Tactical Medicine News
COV-BARRIER Addendum Study: Baricitinib in ECMO/Mechanically Ventilated Patients with COVID-19
Background: Despite access to vaccines in developed countries, COVID19 remains a nimble and persistent foe. While case counts wax and wane the vir...
Tactical Medicine News
REBEL Cast Ep103: Outpatient COVID-19 Therapy
I was fortunate enough to record a podcast on Rob Orman’s, Stimulus podcast on Oct 14th, 2021. We both felt it was an important enough topic that ...
Tactical Medicine News
SAEM Clinical Image Series: Pediatric Rash
A previously healthy 8-year-old female presents to the pediatric emergency department due to a rash. Her symptoms started three days prior to prese...
Tactical Medicine News
The DisCoVeRy Trial: Remdesivir in COVID-19 – An Expensive Version of Tamiflu?
Background: Since the beginning of the pandemic, hundreds of trials have been performed looking at medications with the potential to be repurposed...
Tactical Medicine News
Stanford’s INFODEMIC Conference on COVID-19 Misinformation: Open-access podcasts
In July 2021, Dr. Vivek Murthy became the first U.S. Surgeon General to declare health misinformation a public health crisis. Specifically, COVID-1...
Tactical Medicine News
The TOGETHER Trial: COVID-19 and Fluvoxamine Take Two
Background: Despite having a safe and effective set of vaccines for COVID-19, there have been some low resource countries in which it has been very...
Tactical Medicine News
Awake Proning for COVID-19 Acute Hypoxemic Respiratory Failure
Background: Awake prone positioning was an intervention adopted early in the COVID-19 pandemic for patients with hypoxemic respiratory failure. Un...
Tactical Medicine News
It’s All About Risk: BNT162b2 mRNA COVID-19 Vaccination vs Natural Infection
Background: The world has been involved in mass vaccination efforts for the last nine months. Since the vaccines were approved, billions of doses h...
Tactical Medicine News
RECOVERY RS: CPAP vs HFNO vs Conventional Oxygen Therapy in COVID-19
Background: Much of the last two years has been both a complete blur and indelibly memorable. This dichotomy is encapsulated by the rapid changes a...
Tactical Medicine News
Rebellion21: Good Vibrations with Corona – Using POCUS in the COVID Era via Eric Chin, MD
In this 18-minute presentation from Rebellion in EM 2021, Dr. Eric Chin, MD describes the role of point-of-care ultrasound in the evaluation of a C...
Tactical Medicine News
The PRIEST Score: Predicting Adverse Outcomes in COVID-19
Background: The limited availability of rapid tests with sufficient sensitivity has been an issue since the beginning of the pandemic. Therefore, ...
Tactical Medicine News
SAEM Clinical Image Series: Pulseless and Painful Blue Leg
A 57-year-old male who works as a truck driver with a history of hypertension, type 2 diabetes, and recent COVID-19 infection presents with right l...
Tactical Medicine News
REBEL Cast Ep100: REVVED UP – COVID-19 Vaccination in the ED
Background:
COVID-19 is now a vaccine preventable illness but, unfortunately, many have not received the COVID-19 vaccine due to a number of reason...
Tactical Medicine News
COVID-19 and Anticoagulation: Full Dose or Prophylactic Dose?
Background: Patients with COVID-19 are at a high risk for the development of venous thromboembolic disease [Link is HERE]. Alveolar capillary micro...
Tactical Medicine News
RECOVERY Trial: The REGN-COV Antibody Cocktail in COVID19
Background: Antibodies targeted at the SARS-CoV2 spike protein are an essential part of the body’s immune response to COVID19 infection. Infection ...
Tactical Medicine News
COV-BARRIER: Baricitinib in Hospitalized Adults with COVID19
Background: Outside of vaccines, effective pharmaceuticals for COVID19 continue to be evasive. Steroids have been a success (in patients who requir...
Tactical Medicine News
From Emergency Medicine to Hostage Negotiation
Earlier this year, my home shop began administering the Johnson & Johnson COVID-19 vaccine to patients in the emergency department (ED). Thirte...
Tactical Medicine News
LIVE-AIR Trial: What the Heck is Lenzilumab?
Background: We have all seen the wide spectrum of illness caused by COVID-19 ranging from asymptomatic disease on one extreme all the way up to cri...
Tactical Medicine News
Data from Israel on the BNT162b2 (Pfizer) mRNA COVID-19 Vaccine
Background: COVID-19 vaccination is ramping up both in the US as well as throughout the world. Randomized clinical trials looking at the efficacy o...
Tactical Medicine News
Data from Israel in Health-Care Workers Vaccinated with 1st Dose of the Pfizer COVID-19 Vaccine
Background: Israel has succeeded in ramping up its vaccination program faster than any nation in the world. In December 2020, Israel began a nation...
Tactical Medicine News
Be Heard In a Respirator Mask
Background: A major challenge during the COVID pandemic is balancing personal protection and communication. Being heard while wearing a surgical ma...
Tactical Medicine News
COVID-19 Update: Convalescent Plasma Therapy & Anticoagulation
Background: Medicine by press release has been an unfortunate reality of the COVID-19 pandemic. This is not the standard many physicians would use...
Tactical Medicine News
COVID-19 Update: Time to Let Go of Convalescent Plasma Therapy
Background: Early observational studies led to the Emergency Use Authorization (EUA) for convalescent plasma therapy (CPT) in the US in August 2020...
Tactical Medicine News
Vitamin D Does Not Decrease Hospital Length of Stay in COVID-19
Background: As the COVID pandemic rages on, we continue to search for treatments to help combat the disease. Severely ill patients commonly have lo...
Tactical Medicine News
The STOIC Trial: Inhaled Budesonide in the Treatment of Early COVID-19
Background: COVID-19 typically starts as a mild illness that progresses over several days. Most treatment interventions for COVID-19 are focused on...
Tactical Medicine News
Does D Stand for Decrease Deterioration + Death? – The Jury is Out for Vitamin D in COVID
Update: This article was removed from the Lancet server on February 19th, 2021 (Link)
Background: Vitamin D deficiency is common amongst criticall...
Tactical Medicine News
The RECOVERY Trial: Tocilizumab
Background: Publication of the RECOVERY trial results on Dexamethasone were game changing – the drug had a clear reduction in mortality in patients...
Tactical Medicine News
BLAZE-1 Final Publication: Monoclonal Antibody Cocktail Part II
Background: One of the many massive challenges of the COVID19 pandemic has been the lack of targeted therapeutics. Extensive efforts have been inve...
Tactical Medicine News
COVID-19 Awake Proning – All Hype?
Background: Facilities around the world have seen surges of COVID-19 pneumonia patients who have required protracted hospitalizations leading to o...
Tactical Medicine News
REBEL Cast Ep93: COVID-19 – A Follow Up on Not Intubating Early and ARDSnet
Back in April 2020, on REBEL Cast episode 79 we sat down to discuss COVID-19. Specifically, we focused on not intubating patients early and why AR...
Tactical Medicine News
COVID-19 Update: Ivermectin
Background: Throughout the COVID-19 pandemic, numerous therapeutic agents have been repurposed and applied empirically and within clinical trials. ...
Tactical Medicine News
COVID-19 Update: The COVID-19 Pfizer Vaccine
Background: The COVID-19 Pfizer BNT162b2 vaccine, let’s just call it the COVID-19 Pfizer vaccine (so I don’t have to keep writing BNT162b2) is a no...
Tactical Medicine News
The ISARIC WHO Clinical Characterization Protocol: Risk Stratification of Patients Admitted to Hospital with COVID-19
Background: SARS-CoV-2 infection has resulted in a high mortality rate, with the majority of deaths resulting from respiratory failure. As waves of...
Tactical Medicine News
COVID-19 Update: The PlasmAr Trial – Convalescent Plasma vs Placebo
Background: Despite limited high-quality evidence, many institutions are currently using convalescent plasma therapy (CPT) in the treatment of COVI...
Tactical Medicine News
BLAZE-1: COVID-19 Neutralizing Antibody (Bamlanivimab)
Background: Throughout the COVID19 pandemic, massive efforts have been invested on the research of effective therapeutics. Much of the research lo...
Tactical Medicine News
Vexed on Vaccines: Vaccine Hesitancy, Fact Immunity, and a Pandemic of Misinformation
It is no secret we are in the middle of a pandemic, the likes of which our generation has never seen. Every day, clinicians care for thousands of p...
Tactical Medicine News
COVID-19 Update: An Interesting Study on Serotonin Antagonism
Background: We have tried to decrease the number of updates on COVID-19, as I am sure everyone is getting tired of all the trials coming out on thi...
Tactical Medicine News
The DANMASK-19 Trial: Masks Not Effective to Prevent COVID-19? Not So Fast!!!
Background: Face masks can reduce transmission of respiratory viruses by both being a potential physical barrier and by reducing droplet transmissi...
Tactical Medicine News
A COVID-19 Update that is Long Overdue
Background: There have been lots of trials sitting on my computer desktop awaiting my review, but like many of you time has been thin from clinical...
Tactical Medicine News
COVID-19: An EBM Take
The Novel Coronavirus 2019, was first reported on in Wuhan, China in late December 2019. The outbreak was declared a public health emergency of in...
Tactical Medicine News
US Expanded Access Program: Convalescent Plasma, Mortality, and COVID-19
Background: Convalescent plasma therapy (CPT) is not a novel treatment modality. It has been used in other illnesses such as SARS, MERS, and Ebola...
Tactical Medicine News
Remdesivir in Moderate COVID-19
Background: There are three randomized clinical trials now published on remdesivir in the treatment of COVID-19 pneumonia (RCT 1, RCT 2, & RCT ...
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