The Use of Tranexamic Acid by TEMS Medics - by Kevin B. Gerold
Tranexamic acid (Cyklokapron) for intravenous use is supplied in 1-gram/100 ml ampules and vials (stoppered vials are preferred for prehospital use). When used for the treatment of severe hemorrhage in adults, the usual dose is a 1-gram loading dose administered intravenously over 10 minutes, followed by a second 1-gram dose infused intravenously over eight hours (for pediatrics, consider 10 mg/kg IV). When administered out of hospital, most instances will require administration of only the loading dose. This medication is most effective when initiated close to the time of wounding and is shown to reduce mortality when given within the first three hours following injury.