The VICTAS Trial: How Many More RCTs do we Need on the Metabolic Cocktail in Sepsis?
April 8, 2021
Background: Since the publication of the before and after Marik trial [1] published in 2016, there have been six randomized clinical trials trying to answer...
Marco Torres
The ATESS Trial: Time to Let Go of the Metabolic Cocktail
October 12, 2020
Background: The only well-established treatments for sepsis and septic shock are antibiotic therapy and source control. Septic shock, the most severe form of sepsis, is...
Pearls from ResusX Rewired 2020
October 10, 2020
From Oct 6th – 8th, 2020, Haney Mallemat (@CriticalCareNow) and his team put on an absolutely amazing online critical care conference called ResusX Rewired. ResusX...
Let’s Get Our ACTS Together: The Metabolic Cocktail and Septic Shock Again
September 14, 2020
Background: Though it’s been stated numerous times on this blog, it bears repeating: the pillars of sepsis care remain early identification of sepsis, early appropriate...
The ORANGES Trial: Why You Can’t Just Read the Abstract
July 16, 2020
Background: The cornerstones of sepsis management continues to include early identification, early appropriate empiric antibiotics, definitive source control, and vasopressors to support end organ perfusion....
The HYVCTTSSS Trial: The “Metabolic Cocktail” in Another RCT
May 18, 2020
Background: Getting the basics right in all illness is vital. In sepsis, this means appropriate use of antibiotics, judicious fluid resuscitation, and early identification. Vasopressor...