An Herbal Hope: Is XBJ A Game-Changer in Sepsis Management?
August 14, 2023
Background: Could Xuebijing (XBJ) catalyze a paradigm shift in sepsis management? XBJ is an herbal compound used in China to manage various inflammatory and infectious...
Marco Torres
Adjunctive Methylene Blue in Septic Shock?
May 29, 2023
Background: Sepsis can induce numerous physiologic derangements. At the most severe end, this includes endothelial dysfunction leading to increased vascular permeability, abnormal nitric oxide metabolism,...
REBEL Cast Ep116: The CLOVERS Trial – Restrictive vs Liberal Fluids in Sepsis-Induced Hypotension
May 18, 2023
Background: IV fluids are part of the standard resuscitation bundle in septic shock, however it is unclear if they provide a significant benefit. These patients...
The LOVIT Trial: Orange Crushed
October 31, 2022
Background: Vitamin C dissociates to ascorbate at physiological pH and is not organically synthesized by the human body. Vitamin C can function as an antioxidant...
The CLASSIC Trial: IV Fluid Restriction in Septic Shock
June 23, 2022
Background: The Surviving Sepsis Campaign guidelines recommend an initial fixed volume of 30mL/kg of IDEAL body weight within the first 3 hours of resuscitation (weak...
EM Quick Hits 36 – Surviving Sepsis, Angle Closure Glaucoma, Bougies, Frostbite, Hot/Altered Patient, Central Cord Syndrome
March 1, 2022
In this month's EM Quick Hits podcast: Brit Long on Surving Sepsis Campaign -2021 Updates, Nour Khatib on rural medicine case - angle closure glaucoma,...
Anton Helman
The VICTAS Trial: How Many More RCTs do we Need on the Metabolic Cocktail in Sepsis?
April 8, 2021
Background: Since the publication of the before and after Marik trial [1] published in 2016, there have been six randomized clinical trials trying to answer...
The ATESS Trial: Time to Let Go of the Metabolic Cocktail
October 12, 2020
Background: The only well-established treatments for sepsis and septic shock are antibiotic therapy and source control. Septic shock, the most severe form of sepsis, is...
Let’s Get Our ACTS Together: The Metabolic Cocktail and Septic Shock Again
September 14, 2020
Background: Though it’s been stated numerous times on this blog, it bears repeating: the pillars of sepsis care remain early identification of sepsis, early appropriate...
The ORANGES Trial: Why You Can’t Just Read the Abstract
July 16, 2020
Background: The cornerstones of sepsis management continues to include early identification, early appropriate empiric antibiotics, definitive source control, and vasopressors to support end organ perfusion....
The HYVCTTSSS Trial: The “Metabolic Cocktail” in Another RCT
May 18, 2020
Background: Getting the basics right in all illness is vital. In sepsis, this means appropriate use of antibiotics, judicious fluid resuscitation, and early identification. Vasopressor...