REBEL Core Cast 100.0 – Alcoholic Ketoacidosis
April 26, 2023
Take Home Points Alcoholic Ketoacidosis (AKA) can present with significant acidemia (pH < 7.00). Despite the significant acidemia, patients with AKA can remain alert and...
Marco Torres
The VICTAS Trial: How Many More RCTs do we Need on the Metabolic Cocktail in Sepsis?
April 8, 2021
Background: Since the publication of the before and after Marik trial [1] published in 2016, there have been six randomized clinical trials trying to answer...
The ATESS Trial: Time to Let Go of the Metabolic Cocktail
October 12, 2020
Background: The only well-established treatments for sepsis and septic shock are antibiotic therapy and source control. Septic shock, the most severe form of sepsis, is...
REBEL Core Cast 40.0 – Wernicke Encephalopathy
September 16, 2020
Take Home Points Wernicke encephalopathy is characterized by ataxia, altered mental status and ophthalmoplegia but patients are unlikely to have all these components Suspect Wernicke...
Let’s Get Our ACTS Together: The Metabolic Cocktail and Septic Shock Again
September 14, 2020
Background: Though it’s been stated numerous times on this blog, it bears repeating: the pillars of sepsis care remain early identification of sepsis, early appropriate...
Wernicke Encephalopathy
May 14, 2018
Definition: Encephalopathy that occurs secondary to thiamine (vitamin B1) deficiency. While Wernicke encephalopathy is reversible with treatment, it can progress to the irreversible Korsakoff’s syndrome if...
Should You Prescribe Oral Thiamine for Chronic Alcoholics?
September 7, 2017
Background: Alcoholism is a chronic disease with a staggering impact on society, costing the nation approximately 100 billion dollars per year, an expenditure greater than the...
Episode 87 – Alcohol Withdrawal and Delirium Tremens: Diagnosis and Management
October 25, 2016
Alcohol withdrawal is everywhere. We see over half a million patients in U.S. EDs for alcohol withdrawal every year. Despite these huge volumes of patients...
Anton Helman